MSUV started its exhibition and publishing activities in 1969, although it officially started its work in May 1966. In the following decades, the museum organized numerous exhibitions of different characters - independent and collective, studio and programmatic, visiting for and from abroad and thematic from its own fund in the Matica Srpska Gallery and the House of the JNA since it did not have a permanent exhibition space. Exhibitions were generally announced with posters. The first series of posters, created in the first years of work, was made using quite simple typographical solutions, as they were printed in the printing house of the Serbian National Theater. Since the beginning of the seventies, and especially during the eighties, more attention has been paid to the design and quality of posters. Since then, the museum occasionally hires famous Novi Sad designers, among whom stand out Miodrag Nedeljković, Ferenc Barat, Branislav Dobanovački, Boško Ševa, Miodrag Miša Nedeljković, Branislav Radošević, Dragan Višekruna, Slobodan Kuzmanović-Kuza, Jovan Lukić, Svetozar Tomić and others. The posters created in that period were printed in high quality, using the screen technique, in the Stojkov printing house in Novi Sad. The museum experienced a certain discontinuity with the publication of posters during the 1990s, and then, a decade later, the practice of regular production and production of posters would revive again.

Since the middle of the eighth decade, MSUV has also included exhibitions dedicated to poster authors, mostly domestic and less often foreign, in its exhibition programs. The highlight of the presentation of poster art in the work of the museum was the retrospective exhibition of graphic design "View through Stojkov Press", which was organized on the occasion of the thirtieth anniversary of the Stojkov Printing House in Novi Sad. The poster collections of MSUV and this printing house are the highest quality and most comprehensive overview of the Novi Sad school of cultural posters.

The MSUV poster collection currently contains over a thousand posters for museum exhibitions made by famous Novi Sad and Vojvodina poster artists, members of the Novi Sad School of Cultural Posters - Jovan Lukić (1942-1991), Miodrag Miša Nedeljković (1927-2004), Svetozar Toza Tomić (1939-2005). , Laslo Kapitanj (1937-2015), Mirko Stojnić (1929-2016), Slobodan Kuzmanov Kuza (1947-2016), Boško Ševo (1948-2019), Doru Bosiok (1950-2022), Branislav Dobanovački, Ferenc Barat, Radule Bošković , Branislav Radošević, Dragan Višekruna, Robert Žomberi, Vaso Krčmar, Oskar Štefan and others, as well as Belgrade graphic designers and artists - Mile Grozdanić, Miodrag Bata Knežević, Aleksandar Pajvančić, Slavimir Stojanović. The collection also includes posters made by fine artists - Kosta Bogdanović (1930-2012), Mira Brtka (1930-2012), Ratomir Kulić (Verbumprogram), Danijel Babić, Happy Trash Production, Danilo Vuksanović, Andrej Tišma, Đula Šanta and the second. The collection also includes a small number of posters by Croatian and Slovenian authors - Milan Vulpe (1918-1990), Vjenceslav Richter (1917-2002), Ivan Picelj (1924-2011), Matjaž Vipotnik (1944-2016), Boris Bućan, as well as several authors from Poland and Romania.

In recent years, the museum has paid special attention to younger generations of graphic designers and authors who deal more intensively with posters by collecting their works and organizing individual and collective exhibitions - Atila Kapitanj, Darko Vuković, Nenad Lazić, Đula Šanta, Jovana Budošan, Dušan Zaklan, Valentina Broštean, Tatjana Dukić Počuč and others. Most of these authors are actively and successfully engaged in the graphic design of books, catalogs and magazines.